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Thursday, April 19, 2012

Daily Newsletter April 19, 2012

Microbiology MOOC title3

Daily Newsletter April 19, 2012

Today's Topic: Tuberculosis

Readings:
Tuberculosis
CDC Website for Tuberculosis. Check out some of the links to learn more about Tuberculosis.
Mycobacterium Tuberculosis
Mycobacterium tuberculosis and Tuberculosis

Tuberculosis is a disease that is still endemic (always present). It is also one of the most highly contagious disease. The infectious does can be a low as one bacterium making it all the way to an aveolus in the lung. Because it is so infectious and contagious, it is a disease that medical personel take very seiously.

Daily Challenge: Write about Mycobacterium tuberculosis and the disease Tuberculosis. One challenge with the organism is that the human body has a hard time eliminating it, so you may want to look into why it is so hard for the body to eliminate.

Wednesday, April 18, 2012

Daily Newsletter April 18, 2012

Microbiology MOOC title3

Daily Newsletter April 18, 2012

Today's Topic: Neisseria gonorrhoeae

Suggested Reading:
Gonorrhea - CDC Fact Sheet
Pelvic Inflammatory Disease (PID)
Gonorrhea Laboratory Information: Characteristics of N. gonorrhoeae and Related Species of Human Origin
Gonorrhoea (Neisseria gonorrhoeae) in the United States


Daily Challenge: Neisseria gonorrhoeae
Write about Neisseria gonorrhoeae. Discuss the organism, the diseases it causes, and how it can reinfect the same host.

Tuesday, April 17, 2012

Daily Newsletter April 17, 2012

Microbiology MOOC title3

Daily Newsletter April 17, 2012

Daily Topic: Nosicomial Infections (specifically Staphyloccocus aureus)

Nosicomial refers to infections that are acquired in health-care environments.
Suggested Readings:


Daily Challenge: Discuss the concept of nosicomial infections and specifically the diseases that can be caused by hospital acquired Staphylococcus aureus. Relate this to the concepts of microbial control, and why it is important to practice medicine underdisinfected and/or sterilized condition.

Monday, April 16, 2012

Microbiology MOOC title3

Daily Newsletter April 16, 2012

Special Announcement: All blogs this week are worth 6pts. They must be uploaded by Sunday April 22.

Today's Topic: Flu

Reading: Seasonal Flu: The Basics
This is a CDC website on the flu.  Browse the topics and read about the flu.

 Genetics of the Influenza Virus
A good short article on influenza genetics and why it is constantly changing.



Daily Challenge: Flu
Write about the flu. Discuss the different aspects including signs and symptoms (what are signs and what are symptoms?). Discuss the changes in the flu virus from a genetics perspective, and look at public health concerns.

Friday, April 13, 2012

Daily Newsletter April 13, 2012

Microbiology MOOC title3

Daily Newsletter                                                      April 13, 2012

Daily Challenge: Your Take What is your take on Environmental and Industrial Microbiology? What are you taking away from this week's topic? What have you learned about applied and environmental microbiology?

Thursday, April 12, 2012

Microbiology MOOC title3

Daily Newsletter April 12, 2012

Today's Topic: Environmental Justice

Readings: The following readings support your daily challenge dealing with Environmental Justice.  These are all short readings to get you started.


Daily Challenge: Environmental Justice
In your own words, describe the concept of Environmental Justice.  How could a microbiologist play a role in environmental justice discussions?  How could environmental injustice affect public health?

Wednesday, April 11, 2012

Microbiology MOOC title3

Daily Newsletter April 11, 2012

Today's Topic: Looking for novel pathways

As discussed today, one microbial endeavor is to discover novel metabolic pathways or products that have applications in the modern world. Here are three research areas influenced by looking for novel pathways (even multispecies pathways).
  • metabolic engineering
    • We've talked a little about this previously.
  • metabolic network analysis
    •  This is looking at the overall metabolic pathways of an organism or a system of organisms, including looking at the relative activities of different pathways.
  • metabolic network reconstruction
    •  As the name implies, this is dealing with reconstructing the entire metabolic network of organisms and even assemblages of organisms.
The idea here is to learn about the metabolic capabilities of an organism (at various conditions) or a community/assemblage of organisms. With this information, researches can maximize a system or even engineer new systems.  But you first must find the systems?  That is the million dollar question.  Some times it is by accident.  Other times it is the product of specific experimental design.  Organisms that degrade oil were "discovered" when people started looking in areas with native oil deposits, and then tried to isolate organisms that grew on specific oil products. 

Currently known organisms could also have novel pathways.  Genomics, Proteomics and Metabolomics can all help find novel pathways.  What is important first is that you start looking.


Daily Challenge:
Discuss the importance of new metabolic pathways and products. Look up some of the recent discoveries. Why is it important that we look for novel pathways? What effect could these have on medicine, industry, or even society?

Tuesday, April 10, 2012

Daily Newsletter April 10, 2012

Microbiology MOOC title3

Daily Newsletter April 10, 2012

Today's Topic: Industrial Fermentation

Reading:
  • Fermentation Technology Abstract
    • This abstract, written by Enzymm: Project Consulting for Life Sciences, is an excellent primer for industrial fermentation.  The PDF is 15 pages, but over all the text is rather short.  You will see references to topics we discussed in bacterial growth.
Industrial fermentation's origin can be found in fermented food.  Cheese making, vinting (wine making), brewing (beer making), and even making kimchi or sauerkraut are accomplished through fermentation.

As microbiologists, you have two uses of the word fermentation.

1)  Fermentation defined as a form of anaerobic respiration in which pyruvate is reduced to an end product such as ethanol or lactic acid.

2)  The growth of large numbers of bacterial or fungal (yeast) cells in order to produce a useful product (enzymes, vitamins, antibiotics, or whole cells).

-  This second definition came from the growth of yeasts to high concentration in order to produce ethanol as an end product (beer, liquor, wine).  In modern uses, the end product of pyruvate reduction is not the only valuable end product.  In industrial fermentation, you don't even have to have anaerobic metabolic pathways; the cells could be using oxygen for aerobic respiration.  The goal though is to get a useful product out of the microbial growth.


Daily Challenge: Your take on fermentation
Using the above reading, your textbook, and any references you find, discuss the idea of industrial fermentation. First give a general overview of what is meant by industrial overview. Look for some topic that interests you, something that you would like to know more about. Write a quick paragraph about it. Industrial fermentation is a broad topic, and one in which whole classes are devoted, so just look for some aspect that interests you.

Monday, April 9, 2012

Microbiology MOOC title3

Daily Newsletter April 9, 2012

Today's Topic: Introduction to Applied and Environmental Microbiology

Microbiology touches all of our lives. We are most familiar with diseases caused by microorganisms, but they are important to other aspects of our life. This also means that there are many career opportunities for people interested in microbiology. Here are a few of the topics that we are going to look at this week:
  • Industrial product formation using microorganisms.
    • Supplements such as yeast extract or whey protein.
    • Biotransformed compounds such as steroids.
    •  Enzymes such as Glucose Isomerase.
    • Antibiotics such as penicillin and streptomycin.
    • Food additives such as agar and vinegar.
    • Alcohol such as ethanol (beer, wine, distilled spirits).
    • Chemicals such as citric acid.
    • Processes include Fermenation and Product Purification.
  • Bioremediation
    • Removal of chemical pollutants using biological (metabolic) means.
  • Biotechnology
    • Gene engineering for hormone production.
    • Recombinant Vaccines.
    • DNA vaccines.
    • Metabolic Engineering.
    • Transgenic Plants (using bacterial genes in plants).
  • Sterilization and Decontamination
    • Including Pasteruization
    • Radiation decontamination of food.
  • Food Preservation and Food Production
    • Various
  • Microbial Communities
    • Agricultural Microbiology.
    • Marine Microbiology.
  • Microbial Ecosystem Studies
    • Nutrient Cycling
    •  Biofilm production
  • Symbiosis among microorganisms.
Above is just a simple list of the various aspects of Applied and Environmental Microbiology.


Daily Challenge: What interests you in Applied and Environmental Microbiology?
Write about some aspect of applied and environmental biology that interests you (not medical). If you want, take a topic from the above list and do a little research about it. What jobs are available? You can go to asm.org (American Society for Microbiology) to look up job listings. This is an opportunity to explore the opportunties of microbiology.

Friday, April 6, 2012

Daily Newsletter April 5, 2012

Microbiology MOOC title3

Daily Newsletter April 5, 2012

Today's Topic: Proviral Genes

Read the following article: Effects of Proviral Integration on Host Gene Expression

It is estimated that 8-10% of human genes are actually viral in origin.  These viral genes provide for a number of important physiological responses.  One of the most important proviral impacts in mammals is the formation and function of the placenta.

Read the following short article:  Proviral protein provides placental function


Daily Challenge:
In your own words, describe how proviruses have impacted human physiology and evolution.

Thursday, April 5, 2012

Daily Newsletter April 5, 2012

Microbiology MOOC title3

Daily Newsletter April 5, 2012

Today's Topic: Influenza

Suggested Reading:

Below are links to a series of short articles on the flu and the influenza viruses. Please read over these articles, as they will help you with today's challenge.

Here is a longer article on Influenza Life Cycle that would also be helpful.

 As discussed in class, one of the critical factors in a viral cycle is the attachment of the virus to the host cell.  In the above diagram, you can see the basic stages of Influenza A.  Attachment, leading to endocytosis.  Uncoating occurs, followed by the viral genome taking over cellular metabolism for the formation of new viral particles.  Finally, the budding of new viral particles.

The image below is another example of the influenza life cycle, but in this diagram, note the formation of the viral spikes in the endoplasmic reticulum and Golgi apparatus.

Make note of the formation and incorporation of viral spikes.

Daily Challenge:
In your own words, describe the Influenza viral "life" cycle. Discuss how the spikes are variable, and how the flu changes from year to year. Discuss the concept of antigenic drift and antigenic shift as it applies to the alterations in the flu and vaccination protocols.

Wednesday, April 4, 2012

Daily Newsletter April 4, 2012

Microbiology MOOC title3

Daily Newsletter April 4, 2012


Today's Challenge: Bacteriophage (Viruses of Bacteria) Using your textbook, online resources, and notes from class, describe the lytic and lysogenic cycles.

Supplemental Resources:
Virus Lysogenic & Lytic Cycle Video

Prokaryotic Transduction



The Origin of Viruses - A good overview of viral evolution.

Monday, April 2, 2012

Daily Newsletter April 2, 2012

Microbiology MOOC title3

Daily Newsletter April 2, 2012

Today's Topic: Introduction to Virology
Suggested Reading: Viral Structure

What is a virus?


Viruses are biological agents that need a host cell in order to carry out standard biological process such as metabolism and replication.

We typically think of viruses in terms of diseases:  Flu, colds, HIV, herpes, etc...



Daily Challenge: Viruses Your task today is to reflect on viruses. The goal is not to talk about the specifics of viruses, but to discuss the importance of viruses to the world.