Daily Newsletter January 27, 2012
Today's Topic:Applications
(http://www.sciencedirect.com/science/article/pii/S1369527410000226)
Abstract: Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering.
This is an opinion article, not a research article. You can consider this as being similar to a review article. The authors will review current research and theory so as to propose their own ideas about the state and future of microbial biotechnology. One focus is on systems biology, which involves work in bioinformatics.
Daily Challenge: Article Analysis
You are to blog about this article. Even if you are new to article analysis, you will find that you can figure out key elements of the paper as you read through the article. To help focus your reading of the paper, consider the following questions:
Please read the following article:
Keith EJ Tyo, Kanokarn Kocharin, Jens Nielsen, Toward design-based engineering of industrial microbes, Current Opinion in Microbiology, Volume 13, Issue 3, June 2010, Pages 255-262, ISSN 1369-5274, 10.1016/j.mib.2010.02.001.(http://www.sciencedirect.com/science/article/pii/S1369527410000226)
Abstract: Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering.
This is an opinion article, not a research article. You can consider this as being similar to a review article. The authors will review current research and theory so as to propose their own ideas about the state and future of microbial biotechnology. One focus is on systems biology, which involves work in bioinformatics.
Daily Challenge: Article Analysis
You are to blog about this article. Even if you are new to article analysis, you will find that you can figure out key elements of the paper as you read through the article. To help focus your reading of the paper, consider the following questions:
- What is the authors' purpose in writing this paper? What do they hope to convey to the reader?
- What is their view on current and future directions of biotechnology?
- What tools do they see as important in biotechnology?
- What do they recommend?
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